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Future of Red Light Therapy

Red Light Therapy: The Future of Health with NorahLux

The health and wellness industry has continuously evolved to incorporate therapies that offer a plethora of benefits. Among them, Red Light Therapy (RLT) has emerged as a beacon of promise. Spearheading this movement is NorahLux, a joint venture between Healthlogics and SuperSauna.

The Science Behind Red Light Therapy

RLT's efficacy isn't just an anecdote; it's scientifically validated. Research continues to unveil the multi-faceted advantages of RLT, which includes its role in bone repair, bone formation, molecular mechanisms and gene expression, and neurological and psychological disorders.

The Mechanism of Photobiomodulation in Bone Repair:

Photobiomodulation involves the use of red or near-infrared light to stimulate, heal, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. The primary mechanism, though still being researched, is believed to revolve around the light's ability to stimulate cellular mitochondria, thus increasing production of ATP (Adenosine Triphosphate) - the main energy currency of cells. This energy surge can then promote cellular functions, including those related to repair and regeneration.

The study by Pomini in 2022 showed that PBMT (Photobiomodulation therapy), when applied to bone defects filled with agents labeled B (demineralized bovine bone) and T (human fibrin sealant), led to a noticeable positive influence on the repair process. So the implication is clear: PBMT can potentiate the healing effect of other therapeutic agents in bone defect treatments. This suggests a synergistic role where PBMT accelerates and enhances the bone healing process. (1)

Allam's research from 2023 delved into the specific wavelength of the diode laser used for PBMT – 650nm. This study emphasized that this particular wavelength significantly improved the healing of bone defects. However, it's essential to note the specificity of treatment combinations. While the 650nm laser on its own showed significant results, its combination with a certain graft material didn't amplify the healing effect. This finding underscores the importance of understanding the individual and combined effects of treatments for optimal outcomes. (2)

A 2023 Leal's study introduced a unique combination for bone repair in animals: The stem extract of Ximenia americana L. incorporated into a GelMA hydrogel, potentiated with LED therapy. The extract might contain compounds that promote bone health and repair. When these compounds are delivered via the GelMA hydrogel – a matrix that can provide structural support to cells – and then stimulated with LED therapy, the overall effect appears to be significantly beneficial for bone repair. (3)

Red Light Therapy and its Role in Molecular Mechanisms and Gene Expression

A study by Mohebbi 2023 found that red light therapy treatments significantly increased the expression of miRNA-26a, BMP, SMAD, RUNX, and OSTREX in treated groups compared to controls. The upregulation of miRNA-26a, BMP, SMAD, RUNX, and OSTREX plays a pivotal role in bone health and regeneration. miRNA-26a promotes osteoblast differentiation essential for bone formation. BMPs, growth factors in the bone milieu, directly induce bone and cartilage formation, while SMAD proteins mediate the BMP signaling pathway. RUNX is a key transcription factor steering osteoblast activity, vital for bone synthesis. While specific details on OSTREX are limited, its increased expression, given the context, likely indicates a bolstered bone metabolism. (4)

Red Light Therapy in Bone Formation and Scaffold Studies

Modern therapeutic advancements are constantly seeking to bridge the gap between the natural and the synthetic. In the realm of orthopedics, this translates into the exploration of scaffolds - synthetic or biological structures that act as templates for tissue regeneration. When paired with Red Light Therapy (RLT) or photobiomodulation, these scaffolds might offer new avenues for optimized bone healing and regeneration. Let's delve into the molecular magic that ensues when bone scaffolds meet red light therapy.

In the 2023 study by Adolpho, μCT and histological techniques revealed that the combination of a scaffold with Mesenchymal Stem Cells (MSCs) and Photobiomodulation (PBM) was most effective in enhancing bone repair. This synergy stems from MSCs' ability to differentiate into osteoblasts and the stimulative power of PBM, with the scaffold providing a structured framework for bone growth. The research further ranked this combination as the top-performing method, followed by other methods in a sequential order of effectiveness. (5)

In Huang's 2023 study, a combination of BG (likely a type of bone graft or bioactive glass) and Photobiomodulation (PBM) was found to synergistically enhance bone regeneration. This combined approach not only boosted the proliferation of human bone marrow mesenchymal stem cells, pivotal for bone repair, but also positively influenced genes associated with bone formation. Concrete evidence of this method's success was further supported by histological and μCT findings, underscoring its clinical potential. (6)

Red Light Therapy in Neurological and Psychological Disorders

Photobiomodulation (PBM) or Red Light Therapy (RLT) has shown promising results beyond orthopedics and skin health. A growing body of research is highlighting the significant therapeutic potential of PBM in treating various neurological and psychological disorders. Here's a deeper dive into these studies and their contributions to our understanding of PBM's role in neurology.

Alzheimer's Disease, a debilitating neurodegenerative disorder characterized by memory lapses and cognitive decline, has historically been a challenging condition to treat, with many pharmacological approaches not producing the desired outcomes. However, a transformative solution appears on the horizon with red light therapy. As highlighted in the 2019 study by de la Torre, a form of red light therapy known as transcranial infrared brain stimulation (TIBS) emerges as a promising non-drug intervention for Alzheimer's. This therapeutic modality leverages the benefits of Photobiomodulation (PBM) to address chronic brain hypoperfusion—a factor linked to cognitive decline in aging—and showcases its potential to be a versatile treatment, having demonstrated effectiveness across a range of neurological conditions like Parkinson's, depression, traumatic brain injury, and stroke. (7)

Depression, a debilitating mental health disorder, often necessitates long-term pharmacological interventions with potential side effects. A study by Salehpour in 2016 presented NIR (near-infrared) laser as a non-invasive therapeutic modality, rivaling the effectiveness of the antidepressant Citalopram. This positions PBM as a potential alternative for treating depressive disorders without the typical drug-related side effects. (8)

Epilepsy is characterized by abnormal brain activity leading to seizures. The treatment options, mainly pharmacological, can sometimes be ineffective and laden with side effects. (9) A study by Torres-Martinez in 2023 introduced PBM as a potential solution, focusing on:

  • Mitochondrial Dysfunction: PBM targets the mitochondria, the powerhouse of the cell, addressing the cellular dysfunction in epilepsy.
  • Safety and Non-Invasiveness: PBM emerges as a safe, non-invasive option that could reduce abnormal neuronal firing, seizure activity, and protect against neuronal death.

Stroke, caused by an interruption of blood supply to the brain, can lead to significant tissue damage and neurological deficits. Rapid intervention is key to minimizing damage.The study by Morse in 2022 sheds light on the use of near infrared light (IRL) in stroke treatment, emphasizing modulation of mitochondrial activity. (10) Modulating mitochondrial activity is pivotal for optimizing energy production, ensuring cell health, regulating programmed cell death, offering therapeutic potential for neurodegenerative diseases, enhancing cellular stress response, and potentially slowing aging processes.

Conclusion

In the face of mounting scientific evidence, Red Light Therapy, championed by brands like NorahLux, presents itself as an indispensable tool in health and wellness. For those inclined to embrace cutting-edge health solutions, NorahLux's LED red light therapy is the way to go.

References:

  1. Pomini, Karina Torres et al. “Use of Photobiomodulation Combined with Fibrin Sealant and Bone Substitute Improving the Bone Repair of Critical Defects.” Polymers vol. 14,19 4170. 4 Oct. 2022, doi:10.3390/polym14194170
  2. Allam, Ahmed F et al. “Efficacy of photobiomodulation using diode laser 650 nm combined with nano-cellulose and nano-amorphous calcium phosphate in bone healing of rabbit tibial defects assessed by H&E staining and computed tomography.” Minerva dental and oral science, 10.23736/S2724-6329.23.04793-9. 15 Sep. 2023, doi:10.23736/S2724-6329.23.04793-9
  3. Leal, Seânia Santos et al. “Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models.” Journal of functional biomaterials vol. 14,9 438. 23 Aug. 2023, doi:10.3390/jfb14090438
  4. Mohebbi, Hanieh et al. “MicroRNA-26 and Related Osteogenic Target Genes Could Play Pivotal Roles in Photobiomodulation and Adipose-Derived Stem Cells-Based Healing of Critical Size Foot Defects in the Rat Model.” Photobiomodulation, photomedicine, and laser surgery, 10.1089/photob.2022.0128. 3 Oct. 2023, doi:10.1089/photob.2022.0128
  5. Adolpho, Leticia Faustino et al. “Mesenchymal Stem Cells Combined with a P(VDF-TrFE)/BaTiO3 Scaffold and Photobiomodulation Therapy Enhance Bone Repair in Rat Calvarial Defects.” Journal of functional biomaterials vol. 14,6 306. 1 Jun. 2023, doi:10.3390/jfb14060306
  6. Huang, Lidong et al. “The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis.” Biomedical materials (Bristol, England) vol. 17,4 10.1088/1748-605X/ac6b07. 13 May. 2022, doi:10.1088/1748-605X/ac6b07
  7. de la Torre, Jack C. “Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia.” Brain pathology (Zurich, Switzerland) vol. 26,5 (2016): 618-31. doi:10.1111/bpa.12405
  8. Salehpour, Farzad et al. “Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis.” Brain research bulletin vol. 144 (2019): 213-222. doi:10.1016/j.brainresbull.2018.10.010
  9. Torres-Martinez, Napoleon et al. “Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection?.” Neural regeneration research vol. 18,7 (2023): 1423-1426. doi:10.4103/1673-5374.360288
  10. Morse, Paul T et al. “Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury.” Biochemical Society transactions vol. 50,5 (2022): 1377-1388. doi:10.1042/BST20220446

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